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Year Number of Results
2008 1
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Page 1
Adverse cardiac remodeling augments adipose tissue ß-adrenergic signaling and lipolysis counteracting diet-induced obesity.
Kolleritsch S, Pajed L, Tilp A, Hois V, Pototschnig I, Kien B, Diwoky C, Hoefler G, Schoiswohl G, Haemmerle G. Kolleritsch S, et al. J Biol Chem. 2023 Jun;299(6):104788. doi: 10.1016/j.jbc.2023.104788. Epub 2023 May 5. J Biol Chem. 2023. PMID: 37150323 Free PMC article.
However, long-term HFD-mediated metabolic stress causes contractile dysfunction in Plin5-Tg mice, which emphasizes the importance of a carefully controlled dietary regime in patients with cardiac steatosis and hypertrophy....
However, long-term HFD-mediated metabolic stress causes contractile dysfunction in Plin5-Tg mice, which emphasizes the importance of a caref …
Adipocyte-specific GPRC6A ablation promotes diet-induced obesity by inhibiting lipolysis.
Mukai S, Mizokami A, Otani T, Sano T, Matsuda M, Chishaki S, Gao J, Kawakubo-Yasukochi T, Tang R, Kanematsu T, Takeuchi H, Jimi E, Hirata M. Mukai S, et al. J Biol Chem. 2021 Jan-Jun;296:100274. doi: 10.1016/j.jbc.2021.100274. Epub 2021 Jan 9. J Biol Chem. 2021. PMID: 33428938 Free PMC article.
We thus generated adipocyte-specific GPRC6A knockout mice, and we found that these animals manifested increased adipose tissue weight, adipocyte hypertrophy, and adipose tissue inflammation when fed a high-fat and high-sucrose diet compared with control mice. ...
We thus generated adipocyte-specific GPRC6A knockout mice, and we found that these animals manifested increased adipose tissue weight, adipo …
CIDEC silencing attenuates diabetic nephropathy via inhibiting apoptosis and promoting autophagy.
Zheng GS, Tan YM, Shang YY, Liu YP, Hu BA, Wang D, Han L, Wang ZH, Zhang W, Ti Y, Zhong M. Zheng GS, et al. J Diabetes Investig. 2021 Aug;12(8):1336-1345. doi: 10.1111/jdi.13534. J Diabetes Investig. 2021. PMID: 33655702 Free PMC article.
RESULTS: DM group exhibited glucose and lipid metabolic disturbance, with hypertrophy of kidneys, damaged renal function, increased apoptosis, decreased autophagy, glomerulosclerosis and interstitial fibrosis. CIDEC gene silencing improved metabolic disorder and insulin re …
RESULTS: DM group exhibited glucose and lipid metabolic disturbance, with hypertrophy of kidneys, damaged renal function, increased a …
Targeting ATGL to rescue BSCL2 lipodystrophy and its associated cardiomyopathy.
Zhou H, Lei X, Yan Y, Lydic T, Li J, Weintraub NL, Su H, Chen W. Zhou H, et al. JCI Insight. 2019 Jun 11;5(14):e129781. doi: 10.1172/jci.insight.129781. JCI Insight. 2019. PMID: 31185001 Free PMC article.
The pathological mechanisms underlying the development of lipodystrophy and cardiomyopathy in BSCL2 are controversial. Here we report that Bscl2-/- mice develop cardiac hypertrophy due to increased basal IGF1 receptor (IGF1R)-mediated PI3K/AKT signaling. ...Collectively, o …
The pathological mechanisms underlying the development of lipodystrophy and cardiomyopathy in BSCL2 are controversial. Here we report that B …
Adipose HuR protects against diet-induced obesity and insulin resistance.
Li J, Gong L, Liu S, Zhang Y, Zhang C, Tian M, Lu H, Bu P, Yang J, Ouyang C, Jiang X, Wu J, Zhang Y, Min Q, Zhang C, Zhang W. Li J, et al. Nat Commun. 2019 May 30;10(1):2375. doi: 10.1038/s41467-019-10348-0. Nat Commun. 2019. PMID: 31147543 Free PMC article.
As compared with control mice, HuR(AKO) mice show obesity when induced with a high-fat diet, along with insulin resistance, glucose intolerance, hypercholesterolemia and increased inflammation in adipose tissue. The obesity of HuR(AKO) mice is attributed to adipocyte hypertrop …
As compared with control mice, HuR(AKO) mice show obesity when induced with a high-fat diet, along with insulin resistance, glucose intolera …
miR-155 Deletion in Female Mice Prevents Diet-Induced Obesity.
Gaudet AD, Fonken LK, Gushchina LV, Aubrecht TG, Maurya SK, Periasamy M, Nelson RJ, Popovich PG. Gaudet AD, et al. Sci Rep. 2016 Mar 8;6:22862. doi: 10.1038/srep22862. Sci Rep. 2016. PMID: 26953132 Free PMC article.
Compared to WT adipocytes, miR-155 KO adipocytes upregulated brown (Ucp1, Cidea, Pparg) and white (Fabp4, Pnpla2, AdipoQ, Fasn) adipogenic genes, and glucose metabolism genes (Glut4, Irs1). miR-155 deletion abrogated HFD-induced adipocyte hypertrophy and WAT inflamm …
Compared to WT adipocytes, miR-155 KO adipocytes upregulated brown (Ucp1, Cidea, Pparg) and white (Fabp4, Pnpla2, AdipoQ, Fasn) adipo …
Adipocyte GR Inhibits Healthy Adipose Expansion Through Multiple Mechanisms in Cushing Syndrome.
Hayashi R, Okuno Y, Mukai K, Kitamura T, Hayakawa T, Onodera T, Murata M, Fukuhara A, Imamura R, Miyagawa Y, Nonomura N, Otsuki M, Shimomura I. Hayashi R, et al. Endocrinology. 2019 Mar 1;160(3):504-521. doi: 10.1210/en.2018-01029. Endocrinology. 2019. PMID: 30649271
In Cushing syndrome, excessive glucocorticoids lead to metabolic disturbances, such as insulin resistance, adipocyte hypertrophy, and liver steatosis. In vitro experiments have highlighted the importance of adipocyte glucocorticoid receptor (GR), but its metabolic roles in …
In Cushing syndrome, excessive glucocorticoids lead to metabolic disturbances, such as insulin resistance, adipocyte hypertrophy, and …
Downregulation of adipose triglyceride lipase promotes cardiomyocyte hypertrophy by triggering the accumulation of ceramides.
Gao H, Feng XJ, Li ZM, Li M, Gao S, He YH, Wang JJ, Zeng SY, Liu XP, Huang XY, Chen SR, Liu PQ. Gao H, et al. Arch Biochem Biophys. 2015 Jan 1;565:76-88. doi: 10.1016/j.abb.2014.11.009. Epub 2014 Nov 28. Arch Biochem Biophys. 2015. PMID: 25436917
ATGL knockout mice suffer from TG accumulation and die from heart failure. However, the mechanisms underlying cardiac hypertrophy caused by ATGL dysfunction remain unknown. In this study, we found that ATGL expression declined in pressure overload-induced cardiac hypert …
ATGL knockout mice suffer from TG accumulation and die from heart failure. However, the mechanisms underlying cardiac hypertrophy cau …
Novel PNPLA2 gene mutation in a child causing neutral lipid storage disease with myopathy.
Zheng S, Liao W. Zheng S, et al. BMC Med Genet. 2018 Sep 17;19(1):172. doi: 10.1186/s12881-018-0683-9. BMC Med Genet. 2018. PMID: 30223778 Free PMC article.
BACKGROUND: PNPLA2 gene mutations cause neutral lipid storage disease with myopathy (NLSD-M) or cardiomyopathies. ...Our data expand the allelic spectrum of PNPLA2 mutations, providing further evidence for genetic and clinical NLSD-M heterogeneity in younger individ …
BACKGROUND: PNPLA2 gene mutations cause neutral lipid storage disease with myopathy (NLSD-M) or cardiomyopathies. ...Our data expand …
19 results